Josep Oriol
Narcis Majos, PhD

he / him

Instructor (Junior Faculty) · Department of Neuroscience
Icahn School of Medicine at Mount Sinai · New York, NY

Neuroimmunology Parkinson's Disease Alzheimer's Disease Single-cell Genomics Spatial Transcriptomics Translational Research Tech Transfer Venture Capital Biotech Startups Consulting

I am an Instructor in the Raj Lab at the Icahn School of Medicine at Mount Sinai, where I study immune dysregulation in neurodegenerative diseases, with a particular focus on Parkinson's and Alzheimer's disease. With more than 10 years of experience in neuroimmunology, I work across genomics, bulk and single-cell transcriptomics, and proteomics — integrating large human cohorts and multi-omics data to uncover disease biomarkers and illuminate the mechanisms that will underpin future therapeutics. Beyond the bench, I am deeply interested in the intersection of biomedicine and business: as a Mount Sinai Innovation Partners Fellow, Nucleate NYC Venture Fellow, and incoming VC Institute Fellow, I support the translation of scientific discoveries into clinical and commercial impact through tech transfer, startup creation, venture capital, and consulting. Outside of work, I enjoy playing volleyball.

Peer-reviewed publications

200+

Citations

1,000+

Patient samples (multi-omics)

Years at Mount Sinai

LinkedIn Publications (PubMed) Download CV Contact

Selected Research & Projects

Peripheral Immune Dysregulation Across the Parkinson's Disease Spectrum

Science

Single-cell RNA sequencing and TCR immune profiling of PBMCs from 100+ donors spanning healthy controls, idiopathic PD, GBA1-PD, and LRRK2-PD. Identified compositional and functional immune alterations — including Treg, cytotoxic CD8, and gamma-delta T cell changes — as potential disease biomarkers and mechanistic drivers.

~407,000 cells · 5 cohorts · Single-cell RNA-seq + TCR-seq · Target: Nature Immunology · Supported by The Silverstein Foundation

Spatial Transcriptomics of Parkinson's Disease Brain

Science

Mapping the spatial organization of neuroinflammation in postmortem PD brain tissue using 10x Xenium Human 5K. Integrating single-nucleus RNA-seq from 100+ donors with spatial data to resolve cell-cell interactions, immune infiltration, dopaminergic neuron loss, and alpha-synuclein pathology at tissue-level resolution.

10x Xenium 5K · Postmortem human brain · snRNA-seq integration

Plasma Proteomics Biomarker Discovery in PD

Science

Leveraging SomaScan plasma proteomics (~9,000 proteins) across 170 samples from idiopathic PD, GBA1-PD, and LRRK2-PD cohorts to identify fluid-based biomarkers that distinguish PD subtypes and track disease progression. Supported by NIH, Google-Calico, Illumina, and Parse Biosciences.

SomaScan · 170 plasma samples · 3 PD subtypes · Multi-omics integration

Gilga-Med — Biotech Venture (Nucleate NYC Activator)

Venture

Selected as one of 17 teams from 276 applicants for the Nucleate Activator NYC final cohort. Supporting Gilga-Med in advancing a novel anti-inflammatory compound (GM310, a phenothiazine derivative) with applications in neurodegeneration and inflammation — from IP strategy and preclinical positioning to VC pitch and startup formation.

Nucleate Activator · 2025–Present · Anti-inflammatory · Neurodegeneration

Technology Transfer & Commercialization

Venture Consulting

As a Fellow at Mount Sinai Innovation Partners (MSIP), conducting technology assessments, market analyses, and IP strategy reviews for academic discoveries. Building decision-support materials for senior leadership to prioritize commercialization pathways for novel therapeutics and diagnostics.

MSIP Fellow · 2025–Present

Pro Bono Consulting — TAP & Net Impact NYC

Consulting

Contributing to The Acceleration Project (TAP) and Net Impact NYC engagements with Johnson & Johnson and Citi, delivering marketing strategy and economic growth materials for Spanish- and English-speaking SMBs, and tracking KPIs to assess program impact.

TAP · Net Impact NYC · 2025–Present · J&J, Citi

Experience & Education

Industry & Venture

2026
Incoming

VC Institute Fellow — Cohort 7

Venture Capital Institute

Structured training in VC investment strategy, deal structuring, and life-science portfolio management.

2025–
Present

Venture Fellow

Nucleate NYC Activator · Gilga-Med

Selected in top 17 teams (of 276 applicants); advancing biotech venture formation, IP strategy, and VC/fundraising.

2025–
Present

Innovation Fellow

Mount Sinai Innovation Partners (MSIP)

Technology assessments, market analyses, IP strategy reviews, and commercialization decision support for senior leadership.

2025–
Present

Director of Outreach

Mount Sinai Consulting Club (MSCC)

Grew external consulting network 70% by securing partnerships across 4 major firms; led 8+ workshops with 70+ attendees, increasing engagement 60%.

2025–
Present

Pro Bono Consultant

The Acceleration Project (TAP) · Net Impact NYC

Consulting engagements with Johnson & Johnson and Citi supporting SMB growth through marketing and economic strategy.

2020–
Present

Advisory Committee Member

Neuropathology Brain Bank & Research CoRE (NPBB), Mount Sinai

Quarterly Dean's CoRE Advisory meetings; strategic input to improve biobank operations and research enablement.

Academic & Research

2024–
Present

Instructor (Junior Faculty)

Dept. of Neuroscience, Icahn School of Medicine at Mount Sinai

Leading NIH-funded and private (Google-Calico, Illumina, Parse Bio) initiatives on neurodegeneration.
Managing a 5-member cross-functional team; end-to-end multi-omics data from 1,000+ patient samples.
Integrating genomics, transcriptomics, proteomics, and clinical data for large-scale biomarker discovery.

2019–2024

Postdoctoral Research Fellow

Dept. of Neuroscience & Psychiatry, Icahn School of Medicine at Mount Sinai

Awarded competitive $150K Silverstein Foundation Fellowship (1 of 11 worldwide).
Reduced single-cell transcriptomics costs by 50%, enabling a 260% increase in patient sample size.
Investigated immune alterations in Parkinson's and Alzheimer's diseases to identify novel fluid-based biomarkers.

2021–2025

Professor — Molecular, Cellular & Genetic Foundations (MCG)

Icahn School of Medicine at Mount Sinai

Ranked best first-year professor by students; group leader and evaluator for 50+ medical students.

2017–2018

Scientific Researcher

Dept. of Physiology & Pharmacology, School of Medicine, University of Cantabria

Explored therapeutic approaches for reversing intellectual disability in Down syndrome, including antibody-based drugs and natural neuroprotective derivatives.

2015–2016

Teaching Assistant — Microbiological Basis of Infection

School of Medicine, University of Lleida

Delivered and supervised lab sessions for 80+ medical students under a competitive teaching grant.

Education

2016–2019

PhD, Molecular Biology & Biomedicine

University of Cantabria, Santander, Spain

Graduated Cum Laude · Award for Best Oral Communication.
Thesis: Dysfunction in the biogenesis of pre-mRNAs and pre-rRNAs in motor neurons of Spinal Muscular Atrophy.

2015–2016

MSc, Biomedical Research

University of Lleida, Spain

2011–2015

BSc, Biotechnology

University of Lleida, Spain

Honors for Best Bachelor's Thesis in graduating class.

Skills & Languages

R Single-cell RNA-seq 10x Xenium SomaScan Proteomics Spectral Flow Cytometry GraphPad FlowJo QuPath / HALO AI Microsoft Office (Certified) Spanish (Native) Catalan (Native) English (Professional) CrossFit Scientific Photography

Josep OriolNarcis Majos, PhD

Josep Oriol
Narcis Majos, PhD